Kidney injuries can happen suddenly and without warning—especially in dogs and cats. Acute kidney injury (AKI) in pets is a medical emergency that requires quick recognition and treatment for the best chance of recovery. In this episode of “Your Vet Wants You to Know,” we’re joined by veterinary internal medicine specialist Dr. Simona Buoncompagni, who shares her expertise in kidneys and dialysis to help pet owners understand this critical condition.
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Understanding Acute Kidney Injury in Pets: Insights from Veterinary Experts
Acute Kidney Injury (AKI) is a sudden occurrence where the kidneys stop functioning correctly, often within hours or days. Pets with AKI may not show immediate signs due to their ability to mask symptoms. Common signs include vomiting, lethargy, increased thirst, and changes in urination. Unlike chronic kidney disease, which progresses slowly over months, AKI develops rapidly and requires emergency attention.
Meet Our Expert: Dr. Simona Buoncompagni
Dr. Simona Buoncompagni brings extensive experience in nephrology, urology, and dialysis. Originally from Italy, she pursued her dream of becoming a veterinary specialist in the United States. Dr. Buoncompangi currently practices at LeadER Animal Specialty Hospital in Boca Raton, FL. She shares her experience with AKI, emphasizing the emotional impact on pet owners and the rewarding nature of restoring health to beloved pets.
What is Acute Kidney Injury in Pets?
AKI refers to a sudden decline in kidney function. Unlike chronic kidney disease, which progresses slowly over time, AKI develops quickly—sometimes within hours or days. Common causes in pets include:
Toxins (e.g., grapes, raisins, lilies, antifreeze, certain medications)
Infections (like leptospirosis or tick-borne diseases)
Poor blood flow to the kidneys (due to dehydration, heat stroke, infections, or anesthesia complications)
Urinary obstruction, especially in male cats
This condition often surprises pet owners because it can affect animals that seemed perfectly healthy just a short time before.

Recognizing the Signs of Acute Kidney Injury in Pets
Early signs of AKI may be subtle. Dr. Buoncompagni explains that pet owners should watch for:
Vomiting or nausea
Loss of appetite
Lethargy or weakness
Decreased or increased urination
Bad breath or oral ulcers
These symptoms can mimic other illnesses, making prompt veterinary evaluation essential.
Diagnosis: How Vets Detect Acute Kidney Injury in Pets
Veterinarians diagnose AKI using a combination of:
Blood tests to assess kidney function (elevated creatinine and BUN levels)
Urinalysis to check for abnormal urine concentration or crystals
Imaging (like ultrasound) to evaluate kidney size, structure, and potential obstructions
Dr. Buoncompagni emphasizes that staging and monitoring kidney values over time help veterinarians determine the severity of injury and response to treatment.

Treatment Options for Acute Kidney Injury in Pets
Treatment depends on the cause and severity. Supportive care may include:
IV fluids to restore hydration and blood flow to the kidneys
Medications to control nausea, vomiting, or blood pressure
Dialysis, which Dr. Buoncompagni specializes in, can be life-saving for pets with severe AKI
Dialysis acts as an artificial kidney, filtering out toxins from the blood when the kidneys cannot and buying time for the kidneys to recover. Dr. Buoncompagni explains the process and its benefits in cases where traditional treatments do not suffice. With the help of specialists, dialysis can improve survival and quality of life in pets with reversible injury, ensuring a chance for recovery. Long-term follow-up with your veterinarian is crucial for monitoring and managing kidney health.
Preventing Acute Kidney Injury in Pets
Prevention is critical in managing the risk of AKI. Owners should be aware of toxic foods such as grapes, raisins, and chocolate, and substances like antifreeze, which are hazardous to pets. Regular veterinary check-ups, vaccinations, and flea and tick prevention also play essential roles in AKI prevention.
Pet Owners and Acute Kidney Injury in Dogs and Cats
Seek veterinary care immediately if your pet shows signs of illness
Avoid known toxins (don’t give grapes or raisins; keep lilies out of homes with cats)
Keep pets hydrated, especially in hot weather
Ask questions if your pet is undergoing anesthesia or taking medications that may impact the kidneys
Potential Complications and At-Home Care
While in-hospital treatment significantly reduces the risks, complications can arise if the pet does not respond to treatment. Post-hospitalization care involves adhering to prescribed medications, maintaining a renal diet, and ensuring hydration. Regular follow-up visits are essential to monitor recovery and catch any early signs of chronic kidney disease.
What Owners Should Know about Acute Kidney Injury in Dogs and Cats
Early detection and swift action are crucial in managing AKI. Close communication between the family veterinarian and specialists enhances the chances of a positive outcome. Pet owners must remain vigilant and proactive, ensuring a comprehensive approach to their pet’s health.
To learn more about this vital topic, including detailed discussions on toxins, infectious diseases like leptospirosis, and preventive measures, tune in to the podcast episode or consult your veterinarian. For pet owners in Florida, Dr. Buoncompagni’s specialty hospital offers advanced internal medicine services, including dialysis.



